Ideal Support Research Articles

Recent Progress on Conversion of Lignocellulosic Biomass by MOF-Immobilized Enzyme.

The enzyme catalysis conversion of lignocellulosic biomass into valuable chemicals and fuels showed a bright outlook for replacing fossil resources. However, the high cost and easy deactivation of free enzymes restrict the conversion process. Immobilization of enzymes in metal-organic frameworks (MOFs) is one of the most promising strategies due to MOF materials' tunable building units, multiple pore structures, and excellent biocompatibility. Also, MOFs are ideal support materials and could enhance the stability and reusability of enzymes. In this paper, recent progress on the conversion of cellulose, hemicellulose, and lignin by MOF-immobilized enzymes is extensively reviewed. This paper focuses on the immobilized enzyme performances and enzymatic mechanism. Finally, the challenges of the conversion of lignocellulosic biomass by MOF-immobilized enzyme are discussed.

Enhanced selective photocatalytic CO2 reduction to CO on AuPd decorated Bi2O2.33 nanosheets

Photocatalytic conversion of carbon dioxide (CO2) into valuable fuels addresses pressing needs for renewable energy and carbon neutrality. However, conventional photocatalytic CO2 reduction on semiconductor is usually limited by sluggish electron kinetics, poor efficiency and low product selectivity. Herein, we developed a bimetallic Au/Pd-decorated Bi2O2.33 ultrathin nanosheet photocatalyst for highly selective CO2 reduction to CO under visible light irradiation. Bi2O2.33 nanosheets self-assembled from nanodots serve as ideal supports for Au/Pd anchoring due to abundant grain boundaries. Systematic characterization reveals the formation of alloyed Au/Pd nanoparticles on the Bi2O2.33 surface, which endowed a superior CO production rate of 436.8 μmol g−1 h−1 with a selectivity of 96.68 % from CO2 photoreduction. Quantum chemical calculations uncover that plasmonic Au/Pd alloys facilitates interfacial charge transfer and CO2 activation to form the CO-yielding intermediate. This work demonstrates an effective strategy for designing bimetallic plasmonic cocatalysts to optimize the photoreduction selectivity and efficiency of semiconductor photocatalysts.

MoS2/graphdiyne nanotube/MXene 3D-interconnected ternary aerogel: A high-performance electrocatalyst for hydrogen evolution reaction

MoS2 is a promising challenger to Pt for the HER, but we must make it more durable before it can take over the hydrogen production scene. This work fabricated and evaluated a hybrid structure of MXene-graphydine nanotube-MoS2 (MGMX) aerogel toward HER. It showed efficient and stable activity H2 evolution with ƞ10 = 109 mV vs RHE and a Tafel slope of 55 mVdec−1. The catalytic performance results from a synergistic interplay between increased exposed active sites and improved charge transfer within the catalyst. The two-dimensional (2D) islands of double-phase MoS2 are directly deposited onto graphdiyne nanotubes (GDNTs) surface, creating a structurally interesting material with interconnected components. The unique combination of sp and sp2 carbon atoms in the graphdiyne (GDY) makes it an ideal support for catalyst material. The combination of high edge density in metallic MoS2, a conducting MXene framework, and the bridging structure of GDNT significantly enhance the overall HER performance of the ternary aerogel structure.

Activity and stability of electrochemically reduced graphene oxide films for applications requiring mixed conductivity

A protonic and electronic conductor composed of partially reduced graphene oxide (GO) has been prepared by electrochemical methods. Conductivity measurements and detailed surface analysis by XPS, FTIR, and Raman methods show that the electrochemically reduced GO (ERGO), prepared under different reduction potentials, exhibits a unique dual (protonic and electronic) conductivity which is tunable by adjusting the surface conditions. Selected removal of the oxygenated groups, evolution of C(sp2)/C(sp3) hybrid carbon structure, and surface structure of ERGO can impact the protonic and electronic transport mechanisms. The ERGO samples reported here are ideal support materials with proper ratios of protonic and electronic transport. The as-prepared ionomer-free and flexible ERGO-supported Pt (Pt/ERGO) electrodes were characterized for oxygen reduction reaction (ORR) reactivity in acidic solution. The results showed not only higher electrochemical surface area (ECSA), but also improved mass activity towards ORR compared to conventional carbon supported Pt catalysts.

An idea to explore: Cultivating the art of proposal writing among graduate students.

Proposal writing is an essential requirement for making progress in academics. Learning this skill necessitates support from a mentor to cultivate effective habits. It entails effective strategies from graduate students, such as literature reading and using online tools. Additionally, they must develop an understanding of resource accountability, system thinking, and considering deadlines as a driving force. Good practices for effective proposal writing also involve planning to summarize the work done in the field. Moreover, it requires ideal mentor support by providing timely assistance, helping students overcome impostor syndrome, sharing successful proposals, and creating a cooperative environment.

The Use of CERIA E-Module to Enhance Parents’ Knowledge and Family Support Practice among Childhood Cancer Survivors Undergoing Chemotherapy

Introduction: Chemotherapy is scientifically demonstrated as an effective modality for childhood cancers. However, despite its therapeutic effects, chemotherapy can induce unpleasant side effects. These adverse effects often cause readmissions and trigger stressful, frightening, and painful experiences. These dreadful conditions may cumulatively affect the quality of life. Family social support has been widely mentioned as a significant factor affecting childhood cancer survivors’ quality of life. That being said, an adequate level of knowledge is needed to achieve the ideal family support for the children. For a long time, the standard method applied for knowledge improvement was direct health education and counseling. However, electronic health education is now considered an excellent alternative to the standard method. This study examined the effect of the CERIA e-module application as an electronic health education media for childhood cancer survivors and their parents and the effectiveness of CERIA e-module in improving parents’ knowledge and family support practice for childhood cancer survivors.
 Methods: This study is a quasi-experimental study employing a total sampling technique. Thirty participants from Rumah Singgah Yayasan Peduli Kanker Anak Bali were recruited for this study.
 Results: Findings from this study showed that CERIA e-module is effective in improving parents’ knowledge (p=0.000; p<0.05) and enhancing skills in delivering adequate care and support for children with cancer (p=0.001; p<0.05).
 Conclusion: Based on the results of this study, the authors suggest that nurses organize novel and creative education media for families with childhood cancer survivors to deliver the health messages more attractively.

Hollow core mesoporous carbon spheres as catalyst support for improved platinum utilization in phosphoric acid fuel cells

Using a well-known sol-gel technique, monodispersed silica spheres measuring 380 nm in size are generated in situ. These silica spheres serve as a template for the synthesis of hollow core mesoporous shell (HCMS) carbon spheres. Inside the pores of the template, a polymer is synthesized using azoisobutyronitrile and divinylbenzene polymerization route. Polymer carbonization followed by template remotion yielded HCMS carbon spheres. This HCMS carbon is mesoporous and offers uniform Pt crystallite distribution for acid fuel cell applications. As-prepared HCMS carbon is examined by field emission gun SEM, TEM, nitrogen adsorption/desorption isotherm (BET surface area and BJH pore size distribution analysis), and apparent density using Helium pycnometry. The HCMS carbon obtained demonstrates a BET surface area of 623 m2g-1, showcasing a uniform pore size distribution centered at 3.8 nm. This specific characteristic renders it an ideal support material for fuel cell catalysts. The electrochemical studies reveal the key parameters like corrosion resistance, bulk electrical conductivity, the electrochemical surface area of Pt chemically deposited on HCMS carbon, and unit fuel cell performance under phosphoric acid environment. These parameters are compared with the standard carbon powder, Vulcan XC72R and a commercial catalyst to evaluate the HCMS carbons’ suitability for fuel cell applications.

Hierarchically porous architecture of metal–organic framework-derived and S induced electron localization of Fe single atom sites for boosted ORR

Metal-organic frameworks (MOFs), with their high specific surface area, excellent stability and high electron transfer ability, are ideal supports for accommodating single metal atoms. However, the low utilisation of single-atom active sites limits the improvement of oxygen reduction reaction (ORR) performance.In this work, NH2-MIL-53(Al), a MOF possessing a mesoporous cage architecture, is used as the precursor to prepare N-doped carbon supports (denoted herein as N-HPC) with a well-defined mesoporous structure through pyrolysis. Thiourea was further employed for S doping and impregnated with a FePc, and heated again to yield Fe@S/N-HPC catalysts rich in accessible FeNx single atom sites. The porous structure is more accessible to Fe center atoms by exposing the active sites, provide easy electron conductivity and facilitate mass transport of ORR-intermediates. The prepared hierarchically porous architecture of NH2-MIL-53(Al)-derived and S induced electron localization of Fe SAs sites exhibit excellent ORR performance in alkaline (E1/2 = 0.88 V) medium.

What Can Chaplains Teach About Cross-Cultural Religious Literacy?

This essay considers how chaplains embody the core tenets of cross–cultural religious literacy. This work begins with empathy and humility and in its ideal supports individuals and institutions in their mission driven work. Every day chaplains and spiritual care providers work across many axes of difference, ideally embodying the mutual engagement which builds mutual respect, mutual reliance, and resilience. This essay provides a brief description of chaplains and their work as well as changes in their training and preparation needed to better prepare them to do this everyday work of covenantal pluralism.

Fine-Tuning Should Make Us More Confident that Other Universes Exist

Abstract This paper defends the view that discovering that our universe is fine-tuned should make us more confident that other universes exist. My defense exploits a distinction between ideal and non-ideal evidential support. I use that distinction in concert with a simple model to disarm the most influential objection—the this-universe objection—to the view that fine-tuning supports the existence of other universes. However, the simple model fails to capture some important features of our epistemic situation with respect to fine-tuning. To capture these features, I introduce a more sophisticated model. I then use the more sophisticated model to show that, even once those complicating factors are taken into account, fine-tuning should boost our confidence in the existence of other universes.

Urea with trifunctional effects: an assistant for high exposure of single-atom active sites on 2D nanosheets via structural transformation

This work proposes a novel molten urea-derived thermal exfoliation strategy to construct two-dimensional carbon nanosheets, enabling the effective regulation of mesopores and full anchoring and exposure of single-atom Fe on the carbon nanosheets.

The fabrication of thin-film nanocomposite membrane for organic solvent forward osmosis via host-guest chemistry of α-cyclodextrin

Organic solvent forward osmosis (OSFO) is a newly developing technology for recovering the organic solvent and concentrating substances. The commercial polyethylene (PE) battery separator is the ideal support for OSFO owing to the low structural parameter, resistance for organic solvents, commercially available and simple preparation process. A novel thin-film nanocomposite (TFN) membrane for OSFO was fabricated on the dopamine (DA)-modified PE support by adding α-cyclodextrin (α-CD) in the polyamide (PA) layer. The inclusion complexes (MPD@α-CD) formed by host-guest chemistry enhanced the stability of the membrane. Because of the Janus path and molecular sieving effect of α-CD, the TFN membrane exhibited superior permeability and selectivity among the recent reports. Moreover, the TFN membrane showed high rejection of Rhodamine B and Oxytetracycline, so it had great potential for solutes concentration. Herein, this work broadens the application of eco-friendly α-CD in membrane field and improves the PE composite membrane for OSFO process.

Boosting Peroxymonosulfate Activation via CoS/MXene Nanocomposite for Rhodamine B Degradation under Simulated Sunlight Irradiation.

Cobalt-based heterogeneous catalysts have been demonstrated as an effective PMS activator for pollutant degradation. However, the limited active sites on their surface lead to an unsatisfactory catalytic efficiency. Immobilizing the catalysts on the support material can be a promising modification strategy to solve this problem. MXene has been considered as an ideal support material due to its unique morphology and physicochemical properties. Therefore, in this work, the CoS-loaded Ti3 C2 MXene (CoS/Ti3 C2 MXene) catalyst for peroxymonosulfate (PMS) activation was successfully synthesized through a solvothermal method. Under the simulated sunlight irradiation, the CoS/Ti3 C2 MXene+PMS system achieved an impressive efficiency in removing the organic pollutant rhodamine B (97.2 % in 10 min). Among the tested catalysts, 30 %-CoS-TC stood out, exhibited a broad pH tolerance from 5 to 9 and maintained robust degradation performance over cycles. Upon detailed analysis, the degradation mechanism revealed the collaborative action dominated by singlet oxygen, and supplemented by photogenerated holes and superoxide radicals in the process. Notably, the sandwich-like structure of MXene played a pivotal role, not only dispersing the CoS particles evenly on the surface of catalysts, but also providing ample space for the active sites, thus accelerating the PMS activation for the degradation of rhodamine B. Overall, this study developed an innovative MXene-based catalyst for the application of environmental remediation.

Enhancing post-diagnostic care in Australian memory clinics: Health professionals' insights into current practices, barriers and facilitators, and desirable support.

Providing integrated and evidence-based support to individuals and families following a diagnosis of dementia is essential in order to optimise their quality of life and assist them to live well. Memory clinics provide multidisciplinary services specialising in the assessment and post-diagnostic treatment of people with dementia. This study sought to identify current practices, barriers and facilitators to provision of postdiagnostic support and to obtain health professionals' opinion of ideal post-diagnostic support to be offered in Australian memory clinics. This was a cross-sectional qualitative exploratory study. Data was collected from health professionals familiar with the process of diagnosis and post-diagnostic support through two expert panel meetings (n = 22). In addition, 5 focus groups (n = 22) were conducted including health professionals who are employed in Australian memory clinics. Data was collected between October 2020 and November 2021. Reflexive thematic analysis was undertaken. Seven themes and three subthemes were identified under the three topics: Current Practices, Barriers and Facilitators, and Desirable Support. Themes relating to Current Practices were: Tailored Communication and feedback about diagnosis; Prescription of medications and follow-up; and Referrals to health and community services. Themes relating to Barriers and Facilitators were: The structure of the current system; Lack of funding; Lack of resources; Call for government investment. Themes relating to Desirable support were: A key/single point of support; Cognitive interventions; and Counselling and education. Post-diagnostic support in Australian memory clinics focused primarily on ensuring people understood their diagnosis, information about postdiagnostic support was provided, and dementia medications were prescribed. There were notable differences in practices in metropolitan compared to regional areas. A key concern was the need for increased funding, particularly to support the establishment of a single point of contact to facilitate continuity of care.

Pyrene and Eu3+ modified mesoporous silica used as a fluorescent probe for ratiometric detection of tetracycline antibiotics

The detection of residual tetracycline antibiotics (TCs) in the aquatic environment is important because of the irreversible damage of TCs to the ecosystem and human health. Considering the photostability, sensitivity, and accuracy of the detection systems, mesoporous SBA-15 silica material was an ideal support matrix for improving photostability because it can protect the optical properties of fluorescent signals. To achieve ratiometric detection (with sensitivity and accuracy), pyrene and Eu3+ as two fluorescent signals were implemented into SBA-15, and an organic–inorganic hybrid fluorescent nanoprobe Py/EDTA-SBA-15@Eu3+ was constructed. In the presence of TCs, the red emission of Eu3+ in the nanoprobe was sensitized, and the fluorescence resonance energy transfer occurred from pyrene to Eu3+, resulting in the increased emission of Eu3+ at 617 nm and the decreased emission of pyrene at 384 nm. By monitoring the fluorescent intensity changes at 617 and 384 nm (F617/F384), the nanoprobe achieved the ratiometric detection of oxytetracycline (OTC) and tetracycline (TC) in the range of 0.20–80 and 0.40–80 μM, respectively, with detection limits of 0.18 nM for OTC and 5.83 nM for TC. In addition, the practical application of the nanoprobe was validated in tap water and honey samples.

Structural Design of π-d Conjugated TMx B3 N3 S6 (x=2, 3) Monolayer Toward Electrocatalytic Ammonia Synthesis.

Single-atom catalysts (SACs) have attracted wide attention to be acted as potential electrocatalysts for nitrogen reduction reaction (NRR). However, the coordination environment of the single transition metal (TM) atoms is essential to the catalytic activity for NRR. Herein, we proposed four types of 3-, 4-coordinated and π-d conjugated TMx B3 N3 S6 (x=2, 3, TM=Ti, V, Cr, Mn, Fe, Zr, Nb, Mo, Tc, Ru, Hf, Ta, W, Re and Os) monolayers for SACs. Based on density functional theory (DFT) calculations, I-TM2 B3 N3 S6 and III-TM3 B3 N3 S6 are the reasonable 3-coordinated and 4-coordinated structures screening by structure stable optimizations, respectively. Next, the structural configurations, electronic properties and catalytic performances of 30 kinds of the 3-coordinated I-TM2 B3 N3 S6 and 4-coordinated III-TM3 B3 N3 S6 monolayers with different single transition metal atoms were systematically investigated. The results reveal that B3 N3 S6 ligand is an ideal support for TM atoms due to existence of strong TM-S bonds. The 3-coordinated I-V2 B3 N3 S6 is the best SAC with the low limiting potential (UL ) of -0.01 V, excellent stability (Ef =-0.32 eV, Udiss =0.02 V) and remarkable selectivity characteristics. This work not only provides novel π-d conjugated SACs, but also gives theoretical insights into their catalytic activities and offers reference for experimental synthesis.

Actual and Ideal Support and Supervision in Clinical Education Settings: Comparing the Perspectives of Nursing Students and Clinical Instructors

Introduction: Nursing is a practical profession in which clinical training is the basic medical training program. Clinical training is so important that it is considered as the core of professional education. The aim of the present study was to compare the perceptions of nursing students and clinical instructors about the actual and ideal support and supervision in a clinical setting. 
 Methods: In this descriptive-analytic study, 130 nursing students and 30 clinical instructors of Gonabad Medical Science University are reviewed via census method. The data collection instrument includes the “Perception of Extent of Support and Supervision Survey” questionnaire which is designed in both real and expected status. The findings were analyzed using SPSS20 software and descriptive and analytical statistics.
 Results: There is a significant difference between the actual and ideal perception of nursing students and clinical instructors in the support and supervision domains, so in the support domain, the expectation of nursing students was not met by clinical instructors, and in the supervision domain, the actual degree of supervision is greater than the students' expectation. However, clinical instructors have believed that the ideal support and supervision of students is provided by the clinical instructor.
 Conclusion: Conclusion: The results indicate that there is a gap in the view of clinical instructors and nursing students towards the actual and ideal support and supervision of students in clinical education environments. This gap may have negative effects on the clinical learning of students.

Scalable Synthesis of Flexible Single-Atom Monolithic Catalysts for High-Efficiency, Durable CO Oxidation at Low Temperature.

The creation of single-atom catalysts in a large-size, high-yield, and stable form represents an important direction for high-efficiency industrial catalysis in the future. Herein, we report a strategy to synthesize flexible single-atom monolithic catalysts (SAMCs) based on the hierarchical 3D assembly of single-atom-loaded oxide ceramic nanofibers. The nanofibers, which can be produced in a continuous and scalable manner, serve as an ideal support for single atoms spontaneously and almost completely exposed at the surface through the Kirkendall effect-enabled in situ ion migration during the spinning process, resulting in both high yield and large loading quantity. Moreover, the hierarchical 3D assembly of these nanofibers into a porous, flexible structure endows the SAMCs with the advantages of sufficient infiltration and oscillation tolerance when faced with high-throughput gaseous media, leading to both high catalytic efficiency and excellent durability. As a proof-of-concept demonstration, a Pt SAMC is synthesized, which exhibits 100% CO oxidation at low temperature (∼170 °C), excellent invariance toward high-frequency (10 Hz) oscillation, and high structural stability from 25 to 300 °C. This work is beneficial for the large-scale production of SAMCs in broad industrial applications.

Toward understanding and enhancing self-determination: a qualitative exploration with autistic adults without co-occurring intellectual disability.

Self-determination is a fundamental human right positively related to quality of life. However, Autistic people are reported to be less self-determined than non-autistic people. We aimed to (1) understand what self-determination means to Autistic people from their perspective, (2) explore their perceptions of current barriers to being self-determined, and (3) learn from Autistic people about how they would like to be supported to be self-determined. Semi-structured interviews were done with 19 Autistic adults without co-occurring intellectual disability. Data were analyzed by three Autistic and two non-autistic researchers through an iterative process of data familiarization, coding, and theme development, informed by reflexive thematic analysis. Autistic Community Partners (ACP) were also engaged throughout the study, and provided substantive feedback on all methods and results. Self-determination held the same meaning for Autistic people as non-autistic people. More specifically, participants discussed having the opportunity and support to make choices and decisions in life without unnecessary control from others. Experiences of self-determination were centered around: (1) lack of opportunity, influenced by ableist expectations and discrimination, and (2) executive processing differences that interfered with choice and decision-making. Desired areas of support related to providing opportunities to (1) make choices and exert autonomy, (2) be supported to unmask and be valued as one's authentic Autistic self, and (3) offering pragmatic support for executive processing differences. Autistic adults desire to be self-determined and can flourish with support, as they determine to be appropriate, which might look different from support commonly offered or sought by non-autistic people. Although individualized support was discussed, the ideal desired support was for an inclusive society that values and respects their neurodivergence, rather than imposing ableist expectations. An inclusive society is only achievable through reduced (or eliminated) stigma and prejudice against Autistic people.

Hinge Strut: A New Septal Strut for Nasal Tip Projection, Definition, and Stability in Latino Noses.

Obtaining ideal support to maintain the nasal tip has been investigated in several rhinoplasty studies. We aimed to describe a support technique, namely the use of a "hinge strut" (HS) for the nasal tip in Latino noses and to evaluate nasolabial angles at 6-months follow-up. In total, 46 Latino patients who had undergone rhinoplasty using the HS technique between June 2021 and June 2022 were recruited in Lima, Peru. All patients had nasolabial angle measurements taken preoperatively and at 1, 3, and 6 months postoperatively in active and passive positions to evaluate angle changes during this 6-month period. We evaluated 38 women and six men aged 18-45 years (mean age, 25.74 years). In the passive position, the mean nasolabial angles were 91.5 degrees preoperatively and 106, 104, and 103 degrees at 1, 3, and 6 months, respectively, postoperatively. In the active position, the mean nasolabial angles were 85.5 degrees preoperatively and 102.6, 99.1, and 98.1 degrees at 1, 3, and 6 months, respectively, postoperatively (P < 0.0001, using Friedman chi-square test). The HS technique is safe and reproducible, with nasal tip maintenance and an adequate angle elevation trend observed at 6-months follow-up. Further studies and longer observation times are necessary to determine longer-term outcomes.